Pharmacokinetic and pharmacodynamic Assignment Example | Topics and Well Written Essays - 750 words

Pharmacokinetic and pharmacodynamic - Assignment Example According to Birkett (2005), response parameters measures in an organism involve aspects like blood pressure, concentration of hormones produced by the drug or severity of side effects. The first point when the curve diverts from the zero scale represents the threshold drug dosage. At this concentration, the drug starts exhibiting desired response from the organism. As concentration increases, the graph gets steeper. This means the levels of response increases together with severity of a drug’s side effects. At extremely high dosage, the curve grows almost flat again meaning adverse biological response and even fatality. Technically, drug response time may delay, causing a wrong response to be measured and plotted in a exposure-response graph. Delay in response is caused by the effect of drug distribution and re-distribution around the body system. When data from such unconventional measurements are plotted, they give either clockwise or anticlockwise hysteresis loops. In pharmacokinetics, hysteresis loops signifies presence of delayed response with changing drug concentration. At times, the hysteresis loop can assume a clockwise direction. An anticlockwise hysteresis loop usually results from the differing responses associated with distribution and re-distribution of the drug’s active components to site of action. On the contrary, a clockwise hysteresis loop occurs when there is rapid tolerance whereby after the first administration, tolerance develops which makes similar drug concentrations to cause different responses. After tolerance is developed, a succeeding dosage of similar concentration causes a greater effect than the first level of concentration. As acknowledged earlier, hysteresis in food or drug compounds results from differing responses associated with similar level of substance concentration. Hysteresis occurs when there is either tolerance of the substance or as an effect of substance distribution properties. Numerous

Licensure Essay Example | Topics and Well Written Essays - 250 words

Licensure - Essay Example According to Guido (2014), the scope of registered nurses is outlined by the Nursing Practice Act (NPA). For this reason, it is necessary for nurses to be aware of various clauses documented in the NPA because they indicate the scope of their activities. Of more importance, the regulations also stipulate factors that determine the working conditions for nurses (Bae, 2012). Nurses should also be aware of the implications of the violating the NPA policies. Like in other professions guided by standard practices, nurses are subjected to varying forms of punishment in the event of violating NPA. According to NCSBN (2011), incidences of malpractices violating the NPA are reported to the Boards of Nursing (BON) in the respective jurisdictions. Investigations into the concerned issues are done, and convicted nurses are subjected to legal prosecution process. Therefore, nurses should be aware that their licensures can be questioned or even revoked following the violations of NPA. Lastly, licensed nurses should be aware that they can perform activities beyond their scope of RN practice. According to Guido (2014), nurses can perform activities beyond their scope based on standards developed by the nursing, medicine and administration. In addition, nurses should be aware that additional factors such as status of healthcare administration can affect their effectiveness in service delivery (Auerbach, Staiger, Muench & Buerhaus, 2012). In conclusion, nurses should be aware of various factors affecting their licensures. In particular, nurses are subjected to various regulations that oversee the quality of their services. In addition, nurses are given additional mandates, such as healthcare administration and performance of activities beyond their usual scope after being licensed. Auerbach, D. I., Staiger, D. O., Muench, U., &